Endocrine Abstracts

Background: Experimental and clinical studies have demonstrated that heritability of diabetes is associated with marked hyperinsulinemia, impaired endothelial function, and inflammatory up-regulation. However, no studies have examined whether a family history of diabetes effects placental maternal and fetal vascular circulation, or placental inflammatory response. The present study was designed to investigate the impact of first-degree family history of diabetes (FHD) on place...

We would like to present the case of a twenty-six year old gentleman whose first presentation to hospital was aged 4 days old. At that time he was thought to be generally unwell with poor feeding and excessively somnolent. During his resuscitation he was found to have extremely deranged serum electrolytes with sodium 122 mmol/l and potassium 14 mmol/l. His electrocardiogram (ECG) was initially noted to be bizarre, with no clear rhythm. After resuscitation with IV fluid, glucos...

68 year old lady was on amiodarone for atrial fibrillation and poor left ventricular systolic function. She was feeling unwell, so she had some blood tests which showed elevated free T4 and suppressed TSH. She did not have a family history of thyroid disease. She did not have a goitre or eye signs. She did not have overt signs of thyrotoxicosis. She was admitted as her heart failure was not controlled and her diuretics were optimised. Her thyroid antibodieswere checked and was...

Mrs XY, 29 years. (gravida: 3 and para 2) was admitted under the obstetricians with severe hyperemesis gravidarum (HG). An ultrasonogram revealed single live foetus of 8 weeks gestation. Her two previous pregnancies were normal with no history of HG. Mrs XY was on levothyroxine 150 μg OD for autoimmune primary hypothyroidism with TPO antibodies of 259 kU/l (0–5.6). She was also taking sertraline 200 mg OD for depression. The hyperemesis settled with i.v. fluids as we...

Mrs XY, 28 years. primigravida was seen for PV bleed. Ultrasonogram confirmed live intrauterine foetus of 8 weeks gestation with no obvious cause for PV bleeding. An OGTT at 21 weeks suggested gestational diabetes. She was referred to Diabetes Nurse led clinic and treated with metformin. Hypertension was recorded and controlled with labetalol and amlodipine. Mrs XY had recurrent admissions for PV bleeds and some polycythaemia. She was seen by the haematologist and a diagnosis ...

Case: A 35-year-old man was referred by the haematologists. He had been previously diagnosed with dilated cardiomyopathy and later underwent a cardiac transplant. Following this, he suffered an anterior wall myocardial infarction with subsequent congestive cardiac failure. A coronary angiogram did not reveal any evidence of allograft coronary artery disease. His medications included diuretics, immunosuppressants and warfarin. There was no significant family history. Clinical e...

A 52-years man was admitted following a Road Traffic Accident.He was a known smoker but usually fit and well. During the road traffic accident he sustained fracture of all four limbs, clavicles, facial bones as well as multiple rib fractures.Following initial stabilisation in ITU he underwent multiple orthopaedic surgeries for his bony fractures over the next 2–3 months.He was then noticed to have elevat...

A 48-year man, referred with symptoms suggestive of phaeochromocytoma and elevated 24 h urinary noradrenalin level. He had a background history of obstructive sleep apnoea, controlled hypertension and obesity. His medications included Amlodipine 10 mg od, Modafinil 200 mg daily, Amitriptyline 10 mg and Rabeprazole.Obstructive sleep apnoea was diagnosed at 39 years. CPAP was tried and later Modafinil 100 mg daily. A few months prior to referral his Modafi...

Background: Eating disorders (ED) are more prevalent in young people with Type 1 diabetes than their peers and the combination is associated with higher levels of mortality. However, ED are often under-identified in paediatric diabetes services. Using quality improvement methodology, a screening pathway for ED was developed. Methods: Questionnaires and semi-structured interviews explored participants’ views regarding a screening pathway and choice o...

Context: Secondary adrenal insufficiency (SAI) has been identified in over 22% of adults using inhaled corticosteroids (ICS).1 This has been co-related with the total daily dose and type of ICS along with individual genetic susceptibility among the subjects using ICS.1,2 Our recent paper suggested that 2.8% of adults with euvolaemic hyponatremia admitted to the hospital had ICS related SAI.3Objective: To determine prevale...